What is the role of zolpidem in the treatment of task-specific dystonia (TSFD)?

Label:chem

Topic
Zolpidem is a widely used hypnotic agent that enhances GABA transmission by selectively activating the GABA-A receptor α1 subunit. It has been reported to improve primary focal and generalized dystonia in some patients, but the mechanisms underlying its therapeutic effects have not been fully investigated.
Answer
Zolpidem significantly improves TSFD by reducing corticomotor output and influencing crucial nodes in higher-order sensory and motor circuits. The study found that zolpidem:
Flattened rest and active input/output curves.
Reduced intracortical facilitation (ICF).
Was associated with hypometabolism in the right cerebellum and hypermetabolism in the left inferior parietal lobule and left cingulum.
Correlations were found between changes in dystonia severity and changes in active input/output curves and brain metabolism.
Patients with lower resting motor threshold (RMT) and higher rest and active input/output curves exhibited a better response to zolpidem compared to placebo.
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