What is the role of zolpidem in the treatment of ischemic stroke?

Label:chem

Topic
Zolpidem is a selective positive allosteric modulator (PAM) of α1-GABA-A receptors, primarily used as a sleep-inducing agent. Clinical reports have shown symptomatic improvement in stroke patients following zolpidem administration, suggesting its potential neuroprotective efficacy in ischemic stroke.
Answer
Zolpidem significantly reduces infarct volume, lowers glutamate levels, and improves motor recovery when administered early (within 1.5 hours) post-reperfusion. It enhances phasic GABAergic signaling via α1-GABA-A receptors, reduces NKCC1 mRNA expression, and suppresses the frequency of cortical spreading depolarizations (CSDs), which are key propagators of secondary neuronal injury. These findings suggest that zolpidem is a promising candidate for drug repurposing in stroke treatment, targeting both early neuroprotection and longer-term functional recovery.
Return to Home Chemical List
Knowledge you may be interested in
What is the reaction mechanism of Klason lignin in a lithium battery system? What are the electrochemical properties of Klason lignin, and how were they characterized in the study? How does the chemical composition of Klason lignin extracted from sunflower husks compare to other types of lignin, and why is this significant? What is the potential use of Klason lignin extracted from sunflower husks in the context of electrochemical applications? How does the torrefaction process affect the decomposition behavior of lignin in wood? What are the kinetic parameters for the decomposition of Klason lignin isolated from beech wood? How does the decomposition behavior of Klason lignin isolated from agricultural residues compare to that from wood? What is the significance of Klason lignin in the pyrolysis of lignocellulosic biomass? Why did the phase III NuTide:121 trial fail to show improved overall survival with NUC-1031? What is NUC-1031 and its role in the treatment of advanced biliary tract cancer (aBTC)? How does zolpidem affect glutamate levels post-stroke? What is the impact of zolpidem on GABAergic markers and chloride homeostasis post-stroke? How does zolpidem affect cortical spreading depolarizations (CSDs) post-stroke? What is the role of zolpidem in the treatment of task-specific dystonia (TSFD)? What role does hydroxylamine play in metal-catalyzed nitrate and nitrite reduction? What is the significance of detecting hydroxylamine in the reduction of nitrate and nitrite? What are the implications of hydroxylamine formation for drinking water purification? How does the presence of hydroxylamine affect the calculation of nitrogen gas selectivity? How can hydroxylamine (HA) be efficiently separated from metal ions to produce high-purity HA? Why is thenoyltrifluoroacetone (TTA) chosen as the carrier in the polymer inclusion membrane (PIM) for separating hydroxylamine (HA)?