What is the impact of zolpidem on GABAergic markers and chloride homeostasis post-stroke?

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Topic
GABAergic signaling and chloride homeostasis, regulated by NKCC1 and KCC2, are crucial for post-stroke recovery. Zolpidem modulates GABAergic signaling by enhancing synaptic GABA transmission via α1-GABA-A receptors.
Answer
Zolpidem does not significantly alter the protein levels of α1-GABA-A receptors or GABA transporters (GAT1-3) but significantly reduces NKCC1 mRNA expression in the frontal cortex on day 3 post-stroke. This suggests that zolpidem modulates post-stroke chloride homeostasis without directly affecting GABAergic protein levels, potentially contributing to its neuroprotective effects.
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