How does zolpidem affect glutamate levels post-stroke?

Label:chem

Topic
Glutamate levels increase during stroke and remain elevated during reperfusion, contributing to neuronal damage. Zolpidem has been shown to counteract elevated glutamate levels by enhancing GABAergic signaling.
Answer
Zolpidem administration significantly reduces elevated glutamate levels in the striatum, with the most pronounced effect observed at 24 hours post-stroke. This reduction persists until day 3 post-stroke, suggesting that zolpidem helps restore neurochemical balance and provides neuroprotection by counteracting glutamate-induced neuronal damage.
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