How does zolpidem affect cortical spreading depolarizations (CSDs) post-stroke?

Label:chem

Topic
CSDs are propagating waves of neuronal depolarization that exacerbate secondary damage in ischemic stroke. Zolpidem has been shown to reduce the frequency of KCl-induced CSDs in an experimental model.
Answer
Zolpidem significantly reduces the frequency of KCl-induced CSDs without altering the wave dynamics or neurovascular coupling. This suggests that zolpidem can mitigate the propagation of CSDs, potentially reducing secondary neuronal injury and promoting functional recovery post-stroke.
Return to Home Chemical List
Knowledge you may be interested in
What is the impact of zolpidem on GABAergic markers and chloride homeostasis post-stroke? How does zolpidem affect glutamate levels post-stroke? What is the role of zolpidem in the treatment of ischemic stroke? What is the reaction mechanism of Klason lignin in a lithium battery system? What are the electrochemical properties of Klason lignin, and how were they characterized in the study? How does the chemical composition of Klason lignin extracted from sunflower husks compare to other types of lignin, and why is this significant? What is the potential use of Klason lignin extracted from sunflower husks in the context of electrochemical applications? How does the torrefaction process affect the decomposition behavior of lignin in wood? What are the kinetic parameters for the decomposition of Klason lignin isolated from beech wood? How does the decomposition behavior of Klason lignin isolated from agricultural residues compare to that from wood? What is the role of zolpidem in the treatment of task-specific dystonia (TSFD)? What role does hydroxylamine play in metal-catalyzed nitrate and nitrite reduction? What is the significance of detecting hydroxylamine in the reduction of nitrate and nitrite? What are the implications of hydroxylamine formation for drinking water purification? How does the presence of hydroxylamine affect the calculation of nitrogen gas selectivity? How can hydroxylamine (HA) be efficiently separated from metal ions to produce high-purity HA? Why is thenoyltrifluoroacetone (TTA) chosen as the carrier in the polymer inclusion membrane (PIM) for separating hydroxylamine (HA)? How does the proton gradient drive the transport of hydroxylamine (HA) in the polymer inclusion membrane (PIM) process? What is the role of electrodialysis (ED) in the PIM-ED process for separating hydroxylamine (HA) from metal ions? How does the initial concentration of hydroxylamine (HA) in the feed phase affect the separation efficiency and purity in the PIM-ED process?