What is the role of pasireotide in the treatment of high-grade malignant neuroendocrine tumors (G3NETs) and neuroendocrine carcinomas (NECs)?

Label:chem

Topic
Pasireotide is a second-generation SSA with a broader affinity for multiple SSTR subtypes, including SSTR1, SSTR2, SSTR3, and SSTR5. It has shown promise in treating other types of tumors due to its ability to inhibit cell proliferation through binding to these receptors.
Answer
The study demonstrated that pasireotide showed a strong antiproliferative effect in the H69 small cell lung cancer cell line, which expresses high levels of SSTR2 and SSTR5. This suggests that pasireotide may be a more effective treatment option for G3NETs and NECs compared to traditional SSAs like octreotide.
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