What is the role of bistramide A in actin binding?

Label:chem

Topic
Bistramide A is a natural product toxin that binds to actin. It is unique in that it binds to a different region of the hydrophobic cleft compared to other toxins.
Answer
Bistramide A binds to the far end of the hydrophobic cleft of actin, forming hydrophobic interactions with residues such as Tyr-133, Val-370, Val-134, Leu-110, and Asn-111. This region has not been extensively studied, and the binding of bistramide A suggests potential for further structural elaboration of ligands targeting this site.
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