How do jaspisamide A and reidispongiolide A interact with actin?

Label:chem

Topic
Jaspisamide A and reidispongiolide A are natural product toxins that target actin. These molecules are known to bind to the same site as gelsolin, an F-actin capping and severing protein, and display potent antitumor activity.
Answer
Both jaspisamide A and reidispongiolide A form hydrophobic interactions with actin. Jaspisamide A interacts with Gly-23, while reidispongiolide A forms a hydrophobic interaction with a pocket composed of Ala-144, Ser-145, Pro-332, Arg-335, Ser-338, and Ile-341. These interactions are critical for their binding and antitumor activity.
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