What is the role of kabiramide C in actin binding?

Label:chem

Topic
Kabiramide C is a natural product toxin that binds to actin, a major component of the cytoskeleton in eukaryotic cells. Actin is involved in various cellular functions such as shape, motility, division, and adhesion, making it an attractive target for cancer research.
Answer
Kabiramide C binds to the hydrophobic cleft of G-actin, forming important hydrophobic and hydrogen-bonding interactions. It mimics the binding of actin-binding proteins like gelsolin and has potent antitumor activity. A study shows that modifications to kabiramide C can enhance its binding efficiency while reducing its molecular mass.
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