What are the known inhibitors of trehalase, and what are their limitations?

Label:chem

Topic
Most identified trehalase inhibitors are carbohydrate derivatives that mimic the binding mode of trehalose, forming hydrogen bonds and hydrophobic interactions with the enzyme's active sites.
Answer
Known inhibitors include validamycins, suidatrestin, trehazolin, salbostatin, and casuarine. These compounds exhibit micromolar to nanomolar inhibitory activity in vitro but are unsuitable as insecticides due to poor in vivo uptake and limited bioavailability.
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