How do bifenox and chlomethoxyfen inhibit OfTreh?

Label:chem

Topic
The inhibitory mechanisms of bifenox and chlomethoxyfen were elucidated through molecular docking and kinetic studies.
Answer
Both compounds competitively inhibit OfTreh by binding to its active sites. Chlomethoxyfen forms hydrophobic interactions with residues like Phe163 and Trp462 and hydrogen bonds with Arg215, Glu282, and Arg280, mimicking the binding mode of trehalose.
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