What is the primary signaling pathway targeted by trans-sodium crocetinate (TSC) to alleviate high-altitude acute lung injury (HALI)?

Label:chem

Topic
HALI is characterized by inflammatory infiltration, oxidative stress, and mitochondrial dysfunction triggered by hypoxia.
Answer
TSC primarily targets the EGFR/PI3K/AKT/NF-κB signaling axis, downregulating its expression to inhibit inflammatory responses, oxidative stress, and restore mitochondrial function.
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