How does diallyl disulfide (DADS) affect cell viability in colorectal cancer cell lines (Caco-2 and HT-29) and non-tumoral HUVEC cells?

Label:chem

Topic
Cell viability was assessed using the resazurin assay after 24 h exposure to DADS (25–600 μM) in Caco-2, HT-29, and HUVEC cells.
Answer
DADS demonstrated cytotoxic effects at high concentrations (400–600 μM) in Caco-2, HT-29, and HUVECs, with HT-29 showing greater sensitivity (46% viability at 200 μM, 31% at 400 μM).
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