How does biotin interact with avidin and streptavidin?

Label:chem

Topic
The strong, highly specific binding between biotin and avidin/streptavidin underlies many immunochemical assays.
Answer
The imidazolidine fragment of the biotin molecule binds with high affinity to avidin (a glycoprotein in egg white) and streptavidin (a tetrameric protein from Streptomyces avidinii), forming the basis for biotin–(strept)avidin bridging systems used in immunoassays.
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