What are the gut-derived tryptophan metabolites measured in the study and how were they quantified?

Label:chem

Topic
A study investigated associations between circulating gut-derived tryptophan (Trp) metabolites and markers of cardiometabolic, vascular, and platelet health in adolescents with obesity. The metabolites were measured by UPLC–mass spectrometry.
Answer
The gut-derived Trp metabolites measured included indole-3-propionic acid (IPA), indoxyl sulfate (IS), indole-3-acetaldehyde (IAAld), indole-3-acetic acid (IAA), indole, indole-3-aldehyde (IAld), indole-acrylic acid (IA), and indole-3-lactic acid (ILA). They were quantified using a validated ultra-performance liquid chromatography-tandem mass spectrometry (UPLC-MS/MS) assay.
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