What is the biochemical role of vitamin D in glucose metabolism during pregnancy?

Label:chem

Topic
Vitamin D (specifically 25-hydroxyvitamin D, 25(OH)D) is a fat-soluble vitamin that plays a role in calcium homeostasis and has been implicated in insulin sensitivity.
Answer
Vitamin D influences glucose metabolism by interacting with pancreatic β-cell vitamin D receptors (VDRs), enhancing insulin secretion and improving insulin sensitivity through calcium-dependent signaling pathways. Deficiency leads to insulin resistance and increased GDM risk.
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