How soluble/bioavailable is the amorphous silica in diatomaceous earth (DE) once ingested?

Label:chem

Topic
Amorphous silica is water-insoluble, so its conversion to a bioavailable form is critical for systemic uptake.
Answer
In the gastrointestinal tract the amorphous silica becomes hydrated and is converted into orthosilicic acid (OSA), the absorbable form of silicon, leading to measurable hepatic accumulation and increased silicon apparent digestibility (SiADC) and absolute absorption coefficients (SiAAC).
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