Why is FR901464 significant?

Label:chem

Topic
FR901464 is a natural product that has shown strong antiproliferative effects in cancer cells.
Answer
FR901464 is a natural product known for its antiproliferative activity against human cancer cells at single-digit nanomolar concentrations. Its target was identified in 2007 as splicing factor 3B subunit 1 (SF3B1), a protein in the human spliceosome.
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