How do deoxyguanosine (dG) and entecavir (ETV) competitively inhibit each other's phosphorylation by deoxyguanosine kinase (dGK)?

Label:chem

Topic
A study investigates the competitive inhibition of dG and ETV phosphorylation by dGK in isolated mitochondria.
Answer
Both dG and ETV competitively inhibit each other's phosphorylation. The IC50 for ETV inhibition of dG phosphorylation is 15.3 ± 2.2 μM, while the IC50 for dG inhibition of ETV phosphorylation is 0.53 ± 0.38 μM. This indicates that dGK has a higher affinity for dG than for ETV, and ETV is a more potent inhibitor of dA phosphorylation than dG phosphorylation.
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