What are the roles of deoxyguanosine kinase (dGK) in the mitochondrial purine salvage pathway?

Label:chem

Topic
Deoxyguanosine kinase (dGK) is responsible for phosphorylating deoxyguanosine (dG) and deoxyadenosine (dA) in the mitochondrial purine salvage pathway. This pathway is crucial for maintaining mitochondrial DNA (mtDNA) integrity.
Answer
dGK primarily phosphorylates deoxyguanosine (dG) over deoxyadenosine (dA) in mitochondria. The study shows that dGK has a much higher affinity for dG than for dA, with dG phosphorylation rates being 10–30 times higher than dA phosphorylation rates across different tissues. This suggests that dGK's primary role is in the phosphorylation of dG rather than dA.
Return to Home Chemical List
Knowledge you may be interested in
What is the role of entecavir (ETV) in inhibiting the phosphorylation of deoxyguanosine (dG) and deoxyadenosine (dA) in mitochondria? How does the amount of triethylborane (TEB) affect the reactivity ratio of ethylene oxide (EO) in the copolymerization with anhydrides? What are the functions of succinic anhydride (SA) and phthalic anhydride (PA) in the copolymerization process? What is the role of tetrabutylammonium chloride (TBACl) in the copolymerization process? What is the role of triethylborane (TEB) in the copolymerization of epoxides and anhydrides? What is the significance of the alternating copolymer structure formed by butyl acrylate (BA) and vinyl butyl ether (VBE)? How does the presence of triethylborane (TEB) affect the structure of the resulting graft copolymer? What is the significance of vinyl butyl ether (VBE) in the graft copolymerization process? How does butyl acrylate (BA) contribute to the formation of graft copolymers with cod collagen? What is the role of triethylborane (TEB) in the synthesis of graft copolymers of cod collagen? How does entecavir (ETV) affect the phosphorylation of deoxyguanosine (dG) and deoxyadenosine (dA) in different tissues? What are the potential implications of entecavir (ETV) inhibiting deoxyguanosine kinase (dGK) in mitochondrial DNA (mtDNA) synthesis? How do deoxyguanosine (dG) and entecavir (ETV) competitively inhibit each other's phosphorylation by deoxyguanosine kinase (dGK)? What are the kinetic properties of deoxyguanosine (dG) and entecavir (ETV) phosphorylation by deoxyguanosine kinase (dGK)? What is the role of 2-methyltetrahydrofuran (2-MeTHF) in the extraction of Actinostemma lobatum kernel oil? What are the primary bioactive compounds found in Actinostemma lobatum kernel oil? What is the impact of solvent type on the oxidative stability of Actinostemma lobatum kernel oil? What are the major fatty acids in Actinostemma lobatum kernel oil? How does 2-methylpentane (2-MP) compare to n-hexane in terms of oil yield and oxidative stability? What is the significance of β-carotene in Actinostemma lobatum kernel oil?