What is the role of tetrahydrofuran (THF) and 2-methyltetrahydrofuran (2-MeTHF) in the reaction?

Label:chem

Topic
A study explores the synthesis of lactams from N-alkenyl trichloroacetamides using THF or 2-MeTHF as solvents.
Answer
Tetrahydrofuran (THF) and 2-methyltetrahydrofuran (2-MeTHF) act as both solvents and radical initiators in the reaction. Under violet light irradiation, these solvents generate radical species that initiate the cyclization process, leading to the formation of lactams. The reactions are carried out under air, demonstrating the solvents' ability to support radical formation in the presence of oxygen.
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