What were the specific conditions used for the synthesis of teriflunomide and moclobemide using twin-screw extrusion?

Label:chem

Topic
For teriflunomide, the study used CDI with CH3CN as a liquid additive at 50°C, resulting in a 77% isolated overall yield. For moclobemide, the optimal conditions included EDC.HCl with DIPEA and CH3CN as a liquid additive at 30°C, yielding 87% in a continuous mode.

From: "Amidation by reactive extrusion for the synthesis of active pharmaceutical ingredients teriflunomide and moclobemide", Chem. Commun., 2023,59, 3439-3442
Answer
For teriflunomide, the optimal conditions were CDI with CH3CN as a liquid additive at 50°C, yielding 77% isolated overall yield. For moclobemide, the best conditions were EDC.HCl with DIPEA and CH3CN as a liquid additive at 30°C, providing 87% yield in a continuous mode. These conditions were tailored to maximize conversion and yield while minimizing reaction time and solvent use.
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