What are the advantages of using a twin-screw extruder for the synthesis of APIs like teriflunomide and moclobemide?

Label:chem

Topic
The study applied the twin-screw extrusion method to synthesize APIs such as teriflunomide and moclobemide. This method allows for continuous processing, which can be more efficient and scalable compared to batch processes like ball-milling. It also minimizes the use of solvents, contributing to a more sustainable synthesis process.

From: "Amidation by reactive extrusion for the synthesis of active pharmaceutical ingredients teriflunomide and moclobemide", Chem. Commun., 2023,59, 3439-3442
Answer
Using a twin-screw extruder for synthesizing APIs like teriflunomide and moclobemide offers advantages such as continuous processing, reduced solvent use, and improved efficiency. This method can be scaled up more easily and provides high yields, making it a more sustainable and cost-effective approach for API synthesis.
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