How does liothyronine affect thyroid function in individuals with MS?

Label:chem

Topic
Thyroid hormones, including T3, are critical for various physiological functions. In the context of MS, liothyronine administration could potentially affect thyroid function, leading to adverse effects such as thyrotoxicosis.

From: "A Phase 1b, Open-Label Study to Evaluate the Safety and Tolerability of the Putative Remyelinating Agent, Liothyronine, in Individuals with MS", Neurotherapeutics, Volume 20, Issue 5, September 2023, Pages 1263-1274
Answer
The study observed changes in serum thyroid function tests, but these changes did not result in clinical thyrotoxicosis. Four out of the initial seven participants required dose reductions due to asymptomatic low TSH levels. After revising the dose escalation schedule, no further dose reductions were needed, and no participants experienced clinical thyrotoxicosis.
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