What is the role of liothyronine (synthetic T3) in the treatment of multiple sclerosis (MS)?

Label:chem

Topic
Liothyronine is a synthetic form of triiodothyronine (T3), a thyroid hormone that is essential for the development of the nervous system, including promoting myelination. It is believed to mediate the majority of important thyroid hormone actions and has the potential to induce reparative mechanisms and limit neurodegeneration in MS by promoting the differentiation of oligodendrocyte precursor cells into mature oligodendrocytes.

From: "A Phase 1b, Open-Label Study to Evaluate the Safety and Tolerability of the Putative Remyelinating Agent, Liothyronine, in Individuals with MS", Neurotherapeutics, Volume 20, Issue 5, September 2023, Pages 1263-1274
Answer
Liothyronine is being investigated for its potential to promote remyelination and neuroprotection in MS. The study found that liothyronine was well-tolerated and did not cause severe adverse events or disease activation in individuals with MS. It also showed potential biological effects within the central nervous system (CNS), particularly in proteins associated with immune function and angiogenesis.
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