Combretastatin A4
CAS number: 117048-59-6
Combretastatin A-4 (CA-4) is a natural anti-cancer agent isolated in 1989 from the African willow tree, Combretum caffrum. A synthetic Combretum caffrum-derived cell-permeable stilbenoid phenol that competes with colchicine tubulin binding and interferes with tubulin polymerization.
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Morphological effects of combretastatin A4 (CA-4) analogues. Endothelial cells (EAhy 926 cells) were exposed to the test compounds and incubated for 2 h at the indicated concentrations. Representative photographs were taken at a magnification of 360ꢂ.
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