What are the physiological activities of pyrrole-2-carboxaldehydes (Py-2-C) derived from microorganisms?

Py-2-C derivatives have been isolated from various microorganisms, including marine sponges and actinomycetes. These compounds have been tested for their biological activities, such as cytotoxicity, enzyme inhibition, and antifungal effects.

From: "Pyrrole-2-carboxaldehydes: Origins and Physiological Activities", Molecules 2023, 28(6), 2599;

Py-2-C derivatives from microorganisms exhibit a range of physiological activities. For example, Mycalazal 2 from Mycale micracanthoxea showed strong cytotoxic effects against various cancer cell lines. Compounds from Mycale cecilia demonstrated cytotoxic effects against several tumor cell lines. Additionally, Py-2-C derivatives from Jiangella gansuensis showed significant anti-inflammatory activity by inhibiting NO production in LPS-treated macrophages. These findings suggest that Py-2-C derivatives from microorganisms have potential applications in cancer therapy and anti-inflammatory treatments.