What are the common adverse events associated with liothyronine treatment in MS patients?

Label:chem

Topic
Given the potential side effects of thyroid hormone analogs, it is important to understand the safety profile of liothyronine in MS patients.

From: "A Phase 1b, Open-Label Study to Evaluate the Safety and Tolerability of the Putative Remyelinating Agent, Liothyronine, in Individuals with MS", Neurotherapeutics, Volume 20, Issue 5, September 2023, Pages 1263-1274
Answer
The most common adverse events reported during the study included gastrointestinal distress, fatigue, headaches, insomnia, and palpitations. These events were generally mild (Grade 1) and self-limiting. One participant experienced bowel incontinence and abdominal pain, which resolved after stopping the study drug. No severe or serious adverse events related to the study drug were reported.
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