What role does the ERF transcription factor OpCBR1 play in the regulation of camptothecin biosynthesis and root growth in Ophiorrhiza pumila?

Label:chem

Topic
Camptothecin is a chemotherapeutic drug widely used to treat various cancers. Ophiorrhiza pumila is an ideal model plant for studying the biosynthetic pathway of camptothecin and its regulation. Ethylene-responsive factor (ERF) transcription factors are known to regulate secondary metabolism in plants, but their involvement in camptothecin production was unclear. In this study, OpCBR1, an ERF transcription factor in O. pumila, was found to have dual roles in regulating camptothecin biosynthesis and root growth.
Answer
OpCBR1 negatively regulates camptothecin biosynthesis by directly repressing the OpIO promoter, reducing camptothecin accumulation. Conversely, it promotes root growth by upregulating auxin and cytokinin-related genes, enhancing biomass. This dual role highlights ERF transcription factors as important regulators of plant metabolism and biomass engineering.
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