What are the 9,10-dihydrophenanthrene derivatives, and what is their role in treating COVID-19?

Label:chem

Topic
The COVID-19 pandemic, caused by the SARS-CoV-2 virus, has led to a global health crisis. The 3-chymotrypsin-like cysteine protease (3CLpro) is a key protein in the viral replication cycle and is considered a promising target for developing antiviral drugs. 9,10-dihydrophenanthrene derivatives have been identified as non-covalent inhibitors of SARS-CoV-2 3CLpro, with potential for treating COVID-19.
Answer
The 9,10-dihydrophenanthrene derivatives act as non-covalent inhibitors of the SARS-CoV-2 3CLpro, effectively inhibiting viral replication. Compounds C1 and C2 showed the most potent inhibitory activity, with IC50 values of 1.55±0.21 mM and 1.81±0.17 mM, respectively. These compounds have potential for further development as orally administered antiviral agents.
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