How does the expression of somatostatin receptors (SSTRs) correlate with the effectiveness of octreotide and pasireotide in treating high-grade neuroendocrine tumors?

Label:chem

Topic
The effectiveness of SSAs in treating NETs is largely dependent on the expression of SSTRs in the tumor cells. Octreotide primarily targets SSTR2, while pasireotide has a broader receptor affinity.
Answer
The study found that high expression of SSTR2 and SSTR5 in the H69 cell line correlated with a strong antiproliferative effect when treated with pasireotide, but not with octreotide. This suggests that the differential expression of SSTR subtypes may be responsible for the lack of response to traditional SSAs and highlights the potential of pasireotide as a more effective treatment option due to its broader receptor affinity.
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