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Resveratrol
CAS number: 501-36-0
Resveratrol is a plant polyphenol found in high concentrations in red grapes that has been proposed as a treatment for hyperlipidemia and to prevent fatty liver, diabetes, atherosclerosis and aging. Resveratrol use has been associated with rare instances of serum enzyme elevations during therapy but has not been convincingly linked to episodes of clinically apparent liver injury.

Related images

Models of the active sites of M. sativa CHS2, DluHKS and PinHKS. The structures of DluHKS and PinHKS were modeled based on the structure of M. sativa CHS2 complexed with resveratrol (PDB code 1CGZ, resveratrol not shown).
Models of the active sites of M. sativa CHS2, DluHKS and PinHKS. The structures of DluHKS and PinHKS were modeled based on the structure of M. sativa CHS2 complexed with resveratrol (PDB code 1CGZ, resveratrol not shown).
DOI: /10.1016/j.phytochem.2008.03.013

Related Questions and Answers

Q: What are the pharmacokinetic challenges of resveratrol, and how do they affect its clinical use?
A: Resveratrol exhibits low oral bioavailability due to extensive first-pass metabolism by cytochrome P450s, UDP-glucuronosyltransferases, and sulfotransferases, resulting in plasma concentrations (0.3–2.4 μM) far below in vitro effective levels (>10 μM).
Q: What mechanisms does resveratrol use to reduce Tau protein hyperphosphorylation?
A: Resveratrol reduces Tau hyperphosphorylation by activating protein phosphatase 2A (PP2A) via disruption of the MID1-PP2A complex, inhibiting GSK-3β and CaMKII, and activating the PI3K/Akt pathway.
Q: How does resveratrol influence amyloid-beta (Aβ) accumulation in Alzheimer's disease?
A: Resveratrol reduces Aβ accumulation by directly binding to monomeric and fibrillar forms of Aβ (1–40 and 1–42), promoting proteasome-dependent degradation of Aβ, and enhancing autophagy via the TyrRS-PARP1-SIRT1 signaling pathway.
Q: What is the chemical structure of resveratrol (RSV), and what is its molecular weight?
A: Resveratrol (RSV) is 3,5,4′-trihydroxystilbene, with a molecular weight of 228.25 g/mol. Its structure features two phenol rings connected by a double styrene bond, containing three hydroxyl (-OH) groups that confer antioxidant and biological activity.