What are aza-bicyclo-[3.3.0]octanes, and why are they important?

Aza-bicyclo-[3.3.0]octanes are a type of chemical motif that are partially or fully saturated versions of cyclopenta[b]pyrrole. This motif is found in various natural products and drug molecules, such as ramipril, meloscine, and a nicotine analogue. There are limited strategies for accessing these compounds, which restricts opportunities to discover new drug-like chemical spaces around such scaffolds.

Aza-bicyclo-[3.3.0]octanes are a motif prevalent in natural products and drug molecules, including ramipril, meloscine, and nicotine analogues. However, limited synthetic strategies for these compounds hinder the exploration of new drug-like chemical spaces.