What is the significance of the selective hydrogenation of dimedone in the context of the fragrance and pharmaceutical industry?

Label:chem

Topic
The selective hydrogenation of dimedone (1) to 3,3-dimethylcyclohexanone (2) is an important reaction for the synthesis of fragrance and pharmaceutical intermediates, particularly for the production of 1-(3,3-dimethyl-1-cyclohexen-1-yl)-4-penten-1-one (3), which has a woody, green odor and is used as a perfuming and/or odor-modifying agent.
Answer
The selective hydrogenation of dimedone to 3,3-dimethylcyclohexanone is significant because it provides a synthetic building block for the fragrance and pharmaceutical industry, enabling the production of key intermediates with high yield and selectivity while avoiding the use of corrosive or toxic reagents.
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