How has bradykinin been utilized in understanding gas-phase H/D exchange mechanisms?

Label:chem

Topic
McLuckey et al. used bradykinin [M+H]+ ions (amino acid sequence RPPGFSPFR) to study gas-phase H/D exchange with DI and D2O, observing bimodal product ion distributions indicative of two non-interconverting ion conformations. Freitas and Marshall also explained bradykinin's H/D exchange with D2O by invoking zwitterions.
Answer
Bradykinin [M+H]+ ions have been employed to explore gas-phase H/D exchange, revealing distinct ion conformations and supporting the role of zwitterions in the exchange process.
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