Why is allosamidin considered a potent family 18 chitinase inhibitor?

Label:chem

Topic
Allosamidin is a pseudotrisaccharide isolated from Streptomyces cultures. It is known to inhibit all characterized family 18 chitinases, with Ki values in the n to range.
Answer
Allosamidin is a broad-spectrum inhibitor that effectively inhibits family 18 chitinases, showing biological activity against insects, fungi, and the Plasmodium falciparum life cycle. Its strong inhibitory properties are due to its structure mimicking an oxazoline intermediate, which is unique to the reaction mechanism of family 18 chitinases.
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