How does the addition of trimetaphosphate (P3m) influence the synthesis of cyclic dipeptides from prolinamide?

Label:chem

Topic
Trimetaphosphate (P3m) is a prebiotic source known to act as a potential activator in the polymerization of biomolecules. The study explores whether P3m can enhance the synthesis of cyclic dipeptides from prolinamide under simulated early Earth conditions.

From: "Local pH variability scenario: Prebiotic synthesis of cyclic dipeptides via prolinamide on the Hadean Earth", Palaeogeography, Palaeoclimatology, Palaeoecology, Volume 651, 1 October 2024, 112402
Answer
The addition of trimetaphosphate (P3m) significantly enhances the yield of cyclic dipeptides from prolinamide. Specifically, the presence of P3m results in a threefold increase in the yield of cycloPro-Pro compared to reactions without P3m. This indicates that P3m plays a crucial role in facilitating the polymerization process, providing further evidence for the importance of phosphorus compounds in prebiotic chemical evolution.
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