Streptomycin, an antibiotic derived from Streptomyces griseus, was the first aminoglycoside to be discovered and used in practice in the 1940s. Selman Waksman and eventually Albert Schatz were recognized with the Nobel Prize in Medicine for their discovery of streptomycin and its antibacterial activity.
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Structures of neomycin (1) and streptomycin (2), and macrocyclic neoaminoglycosides 3 and 4.
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