Why is piperidine considered a crucial pharmacophore in drug discovery?

Label:chem

Topic
Piperidine is a crucial pharmacophore and special scaffold in the realm of drug discovery. It is a heterocyclic structure with a six-membered ring, made up of five methylene groups (-CH2-) and one amine group (-NH-).
Answer
Piperidine's flexibility increases the molecule's capability to bind to the receptor, improving the interaction of drug molecules with their targets and enhancing their pharmacokinetic properties. It also improves metabolic stability, increases water solubility, helps solve drug resistance issues, and can easily cross cell membranes.
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