Competition curves of naltrexone (◼) and compounds 8 (△), 9 (▼), 10 (+), 12 (▲), 15 (◇), 31 (○) and 32 (●) for [3H]-DAMGO binding to Wistar rat forebrain membranes.
Biologically important molecules containing C3-functionalized oxindoles or a,b-unsaturated ketones, and the design strategy of combinatorial chemistry for new compound.