Coumarin
CAS number: 91-64-5
Coumarin is a chromenone having the keto group located at the 2-position. It has a role as a fluorescent dye, a plant metabolite and a human metabolite. Coumarin and its derivatives possess anticancer activity against different types of cancers such as prostate, renal, breast, laryngeal, lung, colon, CNS, leukemia, malignant melanoma.
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Dramatic acceleration of the metalation of coumarin (5) and quinoxaline (8) with TMP2Zn·2MgCl2·2LiCl (4) and the new sequential procedure.
Ring expansion of γ-lactone to δ-lactone: Synthesis of chromenone
Profluorescent thiopeptides for monitoring protease activity. Thioamide (denoted by the one or three letter code of the corresponding natural amino acid with a prime symbol, e.g., L′) substrates can be prepared on solid phase from benzotriazole precursors and fluorescent amino acids such as 7-methoxycoumarin-4-ylalanine (μ). Incubation of a coumarin/thioamide labeled peptide with a protease results in cleavage and a concomitant gain of fluorescence.
Synthesis of 7-DMNPB-coumarin-NTA, 7-acetylcoumarin-NTA and 7-acetylcoumarin-NDA.
Palladium-catalyzed C–H bond activation–carbonylation of 2-arylphenols for syntheses of benzopyranones.
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