Cathepsin B
CAS number: 9047-22-7
A lysosomal cysteine proteinase with a specificity similar to that of PAPAIN. The enzyme is present in a variety of tissues and is important in many physiological and pathological processes. In pathology, cathepsin B has been found to be involved in DEMYELINATION; EMPHYSEMA; RHEUMATOID ARTHRITIS, and NEOPLASM INVASIVENESS.
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Effect of varying concentrations of chalcone hydrazones (I), 1,3,5-triphenyl-2-pyrazolines (II), N-acetyl-3,5-diphenyl pyrazolines (III), 3,5-diphenyl-2-pyrazolines (IV) and 1,3,5-triphenyl-2-pyrazoles (V) at pH 6.0 on cathepsin B activity in presence of 2.5 mM concentration of BANA. Results are the mean of the experiment conducted in triplicates taking different concentrations of compounds. Activities are expressed as percent of control which contains equivalent amount of solvent and Lineweaver–Burk plot for cathepsin B activity on varying concentrations of BANA in presence of minimum concentration of chalcone hydrazones (VI), 1,3,5-triphenyl-2-pyrazolines (VII), N-acetyl-3,5-diphenyl pyrazolines (VIII), 3,5-diphenyl-2-pyrazolines (IX) and 1,3,5-triphenyl-2-pyrazoles (X).
Proposed mechanism for inhibition of cathepsin B.
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