Diisopropylcarbodiimide
CAS number: 693-13-0
Diisopropylcarbodiimide has been used in industry as a stabilizing agent, coupling agent, and condensing agent. The potential for exposure exists during the synthesis of polypeptides and other chemicals in the chemical and pharmaceutical industries, as well as during protein synthesis in the recombinant DNA industry.
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Preparation of 2–5. a) pentafluorophenol, 1,3-diisopropylcarbodiimide, CH2Cl2; b) 2-phenylethylamine, 4-aminobutyric acid, or methylamine hydrochloride, iPr2EtN, DMF, 49% (13a), 70% (13b), or 68% (13c) yield for two steps; c) Ac2O, pyridine, then (for 4 and 6) H2O/dioxane, 99% (3), 81% (4), 90% (5), or 97% (6).
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