1-Piperazinesulfonamide is a sulfonamide derivative of piperazine, featuring a six-membered piperazine ring with two nitrogen atoms at positions 1 and 4. The sulfonamide group (–SO2NH2) is attached to one of the nitrogen atoms, contributing to its potential biological activity, particularly as an enzyme inhibitor or antimicrobial agent.
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Potent and selective piperazine sulfonamides as 11β-HSD1 inhibitors.
“Normal” and “reverse” binding modes of piperazine sulfonamides as 11β-HSD1 inhibitors in human 11β-HSD1 enzyme.
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