γ-Aminobutyric acid
CAS number: 56-12-2
Gamma-aminobutyric acid (GABA) is an inhibitory neurotransmitter. It lessens a nerve cell's ability to receive, create or send chemical messages to other nerve cells.
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Preparation of 2–5. a) pentafluorophenol, 1,3-diisopropylcarbodiimide, CH2Cl2; b) 2-phenylethylamine, 4-aminobutyric acid, or methylamine hydrochloride, iPr2EtN, DMF, 49% (13a), 70% (13b), or 68% (13c) yield for two steps; c) Ac2O, pyridine, then (for 4 and 6) H2O/dioxane, 99% (3), 81% (4), 90% (5), or 97% (6).
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