N-Methoxycarbonylmaleimide
CAS number: 55750-48-6
N-Methoxycarbonylmaleimide, also known as N-(Methoxycarbonyl)maleimide, is a synthetic organic compound. It's a maleimide derivative, meaning it contains a five-membered ring with two carbonyl groups and a nitrogen atom. The methoxycarbonyl group (-COOCH3) is attached to the nitrogen, making it a useful reagent for introducing a maleimide group into other molecules.
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Synthesis of alkyne terminated heterobifunctionalized OEG linkers. Reagents and conditions: (a) Propargyl bromide, NaH, THF, 0 °C–RT–60 °C, 15 h; (b) 4-nitrophenyl chloroformate, pyridine, MeCN, RT, 15 h; (c) MsCl, Et3N, DCM, 0 °C–RT, 3.5 h; (d) NaI, acetone, 65 °C, 15 h; (e) KSAc, DMF, RT, 15 h; (f) LAH, THF, −10 °C–RT, 3 h; (g) Potassium phthalimide, DMF, 110 °C, 15 h; (h) Hydrazine, EtOH, 60 °C, 3 h; (i) N-methoxycarbonyl maleimide, Sat. aq NaHCO3, 0 °C–RT, 2 h.
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