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K-11777
CAS number: 233277-99-1
K-11777 is a cysteine protease inhibitor that acts as a broad-spectrum antiviral, by targeting cathepsin-mediated cell entry.

Related images

Michael acceptor inhibitors.
Michael acceptor inhibitors.
DOI: /10.1002/cmdc.201500204
a) Docking pose of inhibitor 6 (magenta) superimposed with K11777 (orange) in complex with rhodesain (PDB ID: 2P7U). b) Proposed docking pose of inhibitor 6 (magenta) in complex with rhodesain.
a) Docking pose of inhibitor 6 (magenta) superimposed with K11777 (orange) in complex with rhodesain (PDB ID: 2P7U). b) Proposed docking pose of inhibitor 6 (magenta) in complex with rhodesain.
DOI: /10.1002/cmdc.201500204

Related Questions and Answers

Q: What is K-11777 and its potential as an antiviral agent?
A: K-11777 is a cysteine protease inhibitor that acts as a broad-spectrum antiviral by targeting cathepsin-mediated cell entry. It was observed to inhibit SARS-CoV virus entry in the sub-nanomolar range, suggesting a potential inhibitory effect on COVID-19 protease. Its dock score was 7.7.