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Lapatinib
CAS number: 231277-92-2
Lapatinib is an organofluorine compound, an organochlorine compound, a member of quinazolines and a member of furans. It has a role as an antineoplastic agent and a tyrosine kinase inhibitor. It is functionally related to a monofluorobenzene.

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Structures of some approved and reported ErbB family inhibitors: Lapatinib, TAK-285
Structures of some approved and reported ErbB family inhibitors: Lapatinib, TAK-285
DOI: /10.1002/ardp.201600197
The alignment between the bioactive conformer of lapatinib (I) (colored in violet) and the docked pose (colored in green) at EGFR binding site.
The alignment between the bioactive conformer of lapatinib (I) (colored in violet) and the docked pose (colored in green) at EGFR binding site.
DOI: /10.1002/ardp.201600197
Left: Docking of lapatinib (I) in EGFR binding site (PDB code: 1XKK) showing H bonds with met793 and π interaction with Lys 745. Right: Docking of (TAK285) (III) in HER-2 binding site (PDB code: 3RCD) showing H bond with met801.
Left: Docking of lapatinib (I) in EGFR binding site (PDB code: 1XKK) showing H bonds with met793 and π interaction with Lys 745. Right: Docking of (TAK285) (III) in HER-2 binding site (PDB code: 3RCD) showing H bond with met801.
DOI: /10.1002/ardp.201600197

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