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Merimepodib
CAS number: 198821-22-6
Merimepodib (VX-497) is a novel noncompetitive inhibitor of IMPDH. Merimepodib is orally bioavailable and inhibits the proliferation of primary human, mouse, rat, and dog lymphocytes at concentrations of approximately 100 nM.

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In a series of IMPDH inhibitors developed by Vertex and Bristol-Myers-Squibb such as (S)-tetrahydrofuran-3-yl 3-(3-(3-methoxy-4-(oxazol-5-yl)phe-nyl)ureido)benzylcarbamate (15, merimepodib, Figure 5) and related inhibitors 16 and 17, the phenyloxazole moiety with an ortho methoxy group was introduced and found to bind at the nicotinamide subdomain of NAD-binding pocket of IMPDH.
In a series of IMPDH inhibitors developed by Vertex and Bristol-Myers-Squibb such as (S)-tetrahydrofuran-3-yl 3-(3-(3-methoxy-4-(oxazol-5-yl)phe-nyl)ureido)benzylcarbamate (15, merimepodib, Figure 5) and related inhibitors 16 and 17, the phenyloxazole moiety with an ortho methoxy group was introduced and found to bind at the nicotinamide subdomain of NAD-binding pocket of IMPDH.
DOI: /10.1021/jm070864w

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