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Gefitinib
CAS number: 184475-35-2
Gefitinib (originally coded ZD1839) is a drug used in the treatment of certain types of cancer. Acting in a similar manner to erlotinib (marketed as Tarceva), gefitinib selectively targets the mutant proteins in malignant cells. It is marketed by AstraZeneca under the trade name Iressa.

Related images

(A) Superposition of 8g (yellow) and gefitinib (2, purple) poses inside the EGFR tyrosine kinase ATP binding site. (B) Binding interactions of 8g (yellow) with EGFRwt. (C) Binding interactions of 8b (magenta) with EGFRwt. (D) Binding interactions of 8e (green) with EGFRwt. (E) Binding interactions of 8k (blue) with EGFRwt. (F) Binding interactions of 8o (light pink) with EGFRwt.
(A) Superposition of 8g (yellow) and gefitinib (2, purple) poses inside the EGFR tyrosine kinase ATP binding site. (B) Binding interactions of 8g (yellow) with EGFRwt. (C) Binding interactions of 8b (magenta) with EGFRwt. (D) Binding interactions of 8e (green) with EGFRwt. (E) Binding interactions of 8k (blue) with EGFRwt. (F) Binding interactions of 8o (light pink) with EGFRwt.
DOI: /10.1016/j.ejmech.2013.10.058

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